yes, realistically it would. that comes out to about... losing 3lbs a week.
With a person at your weight (which will burn more calories running 2miles than someone who weighed 150 running 2miles), 3lbs a week is in the realistic range.
Just make sure you ease into things, so you dont end up hating and dreading workouts after the second month. Its a lifestyle change, and once you start... you keep feeling better from there.
But most importantly, follow a proper diet that is suited for weightloss. That is by far the most important step.
good luck