First of all you need to determine your calorie needs. There are seveal calculators out there is you do a search for BMR calculator, you can find one. Once you have determined how many calories your body burns daily, reduce this amount by 20-25%. You need a calorie deficit to reduce your weight. Spread these calories out over 5-6 meals a day, roughly 3 hours apart. Stick with lean proteins, whole grains, lots of fruits and veggies and good fats.
Definately incorporate a weight program into your activities. I recommend to start out with a full body workout 3 days a week. Concentrate on your compount lifts (Bench, Deadlifts, Squats, Shoulder Press, etc.) and maybe finish up with a 2 isolation movements (curls, leg extensions and curls, tricep presses).
As far as cardio, it is a good idea to keep cardio as part of your training, however start out slow. Maybe perform a brisk walk 3-4 nights a weeks until you shed a little weight and get your stamina up. Any activity is better than none at all.
I wish you all the luck in your goal to lose weight. There are a lot of knowledgeable people on this site and are more than happy to offer some great information. I recommend using the search engine on the site and read around the forums to get more detailed information.
I would also recommend consulting your physician before starting any exercise program. Good Luck!
