Hallo leute
Ich habe hier einen tollen Artikel in einem Forum gefunden. Ist leider English, aber mich würde interessieren was ihr davon haltet !
The Art of Spot Reduction
Editor´s Note: Darkham is doing some interesting work on a new method of fat reduction. Adipocytes are not long-lived in the same way that nerve cells are, so they must be replaced when they expire. By blocking the transition of pre-adipocytes to adipocytes we can lower the number of fat cells in the body, which is a more effective way to reduce fat than reducing the size of the Cells. I held back this article initially because I wasn´t sure that there really were Beta2 receptors on fat cells. But Dharkam supplied the reverences showing that this really is the case.
Why do we always have that last spot of fat when everything else is gone? If you learned all the food
markets in your area were going on strike, what would you do? You'd probably stockpile and hoard food, wouldn't you?
In a similar way, the body holds on to calories in case you're not able to find anything to eat anymore. For women it is even tougher because they need to have enough calories in they form of fat to bring a pregnancy to term.
The surface of the fat cells contains two kinds of biochemical receptors:
The ones which open the door and empty the warehouse (let's call them the good receptors),
and the ones which do anything to keep the door closed and prevent the emptying (let's call them the bad receptors).
Needless to say, the last spots of fat contain a lot of the latter and few of he former:
Our strategy is to activate the good receptors while putting the bad ones out of order. We don´ t want to do this everywhere in the body. Only in very specific last spots of fat. We're going to make a surgical strike, but instead of smart missiles, we're using hypodermic needles.
The goal is to increase the level of a substance called cAMP (cyclic Adenosine Mono Phosphate).
cAMP is good stuff. The more of it we have in the lat cells, the quicker we can get rid of them.
Our weapon to accomplish this is called a beta agonist. The most popular is injectable clenbuterol. But injectable albuterol is as good for fat loss and easier to find. What you do not want to use is an injectable beta agonist which is not specific for the beta receptors such as epinephrine or norepinephrine.
Once injected, the beta agonist will increase cAMP in fat cells and will start to slowly open the lock. Unfortunately, there is an alarm on the lock. Once camp level is increased in fat cells an enzyme called phosphodiesterase (PDE) will appear. This PDE is the first enemy we meet as PDE will reduce the level of camp by destroying it. So now that we´ ve softened up the enemy with beta agonists we have to defeat the PDE reaction force. Our weapon for this battle is called a phosphodiesterase inhibitor. There are many on the market – the best being Amrinone and Milrinone. But they are hard to find. In the event a PDE inhibitor ca not be found, less specific ones can easily be found.(Note Trental doesn´t work)
So in this case we´ re left either theophylline or caffeine. Remember only when injected locally can those two drugs reach the critical concentration needed to effectively destroy PDE. Taken orally, one will never benefit from these properties of the drugs. So injecting a beta agonist and a PDE inhibitor will greatly accelerate fat loss where injected.
First the alpha2 receptors. Thera are drugs to destroy the receptors themselves but this require a few weeks.
(Gemeint sind hier die ACE Hemmer wie Captopril!!!)
So we´re going to use the next best quick solution – block them. We´re going to lay down a mine field with the help of an injectable drug called atipamezole. This is the perfect tool for the job…it´s not easy to find. Most will have settle for second best, which is yohimbine. Easy to find for oral use, but not for injections. Well, that doesn´t matter much. If don´t want to use it mixed with DMSO, ingestion is not that bad (but not best)
The last of the enemy´s forces are called adenosine receptors. The more the camp rises, the more adenosine will be found in the fat cells. This is because when camp is degraded it produces adenosine. It´s a negative feedback used by the body to make sure you are not losing fat too fast. We need to take care of the adenosine receptors by blocking them. Theophylline or caffeine will do the trick. If Amrinone is used, then theophylline will have to be used along with it. We have to burn the fat otherwise it will redeposited. This is called re-esterification. And when the fat is re-esterified it´s always in the wrong place.
The classic non-dieting way of ridding fat is weight training an aerobis
When we say aerobics, we do not mean slow speed 60% of your heart rate. We mean maximum speed. Enough energy is in the blood to stand it. Aerobics should be done first thing in the morning on an empty stomach. During the night, the body will have wasted all its carb-energy and will already rely on fat calories for energy. Absolutely NO eating beforehand. For two reasons:
1. Eating will bring in calories and so will spare fat calories we have in the blood.
2. Eating while taking a beta agonist an alpha 2 antagonist will result in a huge boost of insulin.
The insulin is like superior artillery which would defeat all of our armament, especially if we're not using the
phosphodiesterase inhibitor (amrinone).
If you're tired that means your body doesn't know how to convert the fat calories into a useable form of energy.
It will learn the hard way if you are waging TCW (total chemical warfare). Train as long as you can. When you cannot stand it any more, have a protein drink (Designer Whey seems to be the best). But remember no carbs. It will make you feel better and you can resume training. ,
Each day your goal will be to postpone the moment you take the drink. It will mean your body is learning how to use its fat for energy. Afterwards eat protein only. Try to postpone carb intake as much as possible. And remember, you're on a diet, don't stuffyour face.
The key is to start very low with only the beta agonist. ln a few days add the PDE inhibitor, then the alpha 2. Remember the doses should build up slowly. Too low a dose start won't hurt, For example, 1/2 a ml of clenbuterol will probably have no discernible effect. Next use day 1ml. See what happens.
Obviously, the injections go into the fat. But you do not want to go too deep. This is where insulin needles (without the insulin) are useful. Furthermore you don't want to inject in the same place everyday. One day high in the right buttock, and next day high in the left; the next day low in the right and so on. Divide the area you want to spot reduce into several squares. Use a different square everyday. You will need several injections to have all the drugs in place. Space those injections a little bit in your square.
Bin auf eure Postings gespannt
Gruß und einen schönen 1. Mai !
Patrick
Ich habe hier einen tollen Artikel in einem Forum gefunden. Ist leider English, aber mich würde interessieren was ihr davon haltet !
The Art of Spot Reduction
Editor´s Note: Darkham is doing some interesting work on a new method of fat reduction. Adipocytes are not long-lived in the same way that nerve cells are, so they must be replaced when they expire. By blocking the transition of pre-adipocytes to adipocytes we can lower the number of fat cells in the body, which is a more effective way to reduce fat than reducing the size of the Cells. I held back this article initially because I wasn´t sure that there really were Beta2 receptors on fat cells. But Dharkam supplied the reverences showing that this really is the case.
Why do we always have that last spot of fat when everything else is gone? If you learned all the food
markets in your area were going on strike, what would you do? You'd probably stockpile and hoard food, wouldn't you?
In a similar way, the body holds on to calories in case you're not able to find anything to eat anymore. For women it is even tougher because they need to have enough calories in they form of fat to bring a pregnancy to term.
The surface of the fat cells contains two kinds of biochemical receptors:
The ones which open the door and empty the warehouse (let's call them the good receptors),
and the ones which do anything to keep the door closed and prevent the emptying (let's call them the bad receptors).
Needless to say, the last spots of fat contain a lot of the latter and few of he former:
Our strategy is to activate the good receptors while putting the bad ones out of order. We don´ t want to do this everywhere in the body. Only in very specific last spots of fat. We're going to make a surgical strike, but instead of smart missiles, we're using hypodermic needles.
The goal is to increase the level of a substance called cAMP (cyclic Adenosine Mono Phosphate).
cAMP is good stuff. The more of it we have in the lat cells, the quicker we can get rid of them.
Our weapon to accomplish this is called a beta agonist. The most popular is injectable clenbuterol. But injectable albuterol is as good for fat loss and easier to find. What you do not want to use is an injectable beta agonist which is not specific for the beta receptors such as epinephrine or norepinephrine.
Once injected, the beta agonist will increase cAMP in fat cells and will start to slowly open the lock. Unfortunately, there is an alarm on the lock. Once camp level is increased in fat cells an enzyme called phosphodiesterase (PDE) will appear. This PDE is the first enemy we meet as PDE will reduce the level of camp by destroying it. So now that we´ ve softened up the enemy with beta agonists we have to defeat the PDE reaction force. Our weapon for this battle is called a phosphodiesterase inhibitor. There are many on the market – the best being Amrinone and Milrinone. But they are hard to find. In the event a PDE inhibitor ca not be found, less specific ones can easily be found.(Note Trental doesn´t work)
So in this case we´ re left either theophylline or caffeine. Remember only when injected locally can those two drugs reach the critical concentration needed to effectively destroy PDE. Taken orally, one will never benefit from these properties of the drugs. So injecting a beta agonist and a PDE inhibitor will greatly accelerate fat loss where injected.
First the alpha2 receptors. Thera are drugs to destroy the receptors themselves but this require a few weeks.
(Gemeint sind hier die ACE Hemmer wie Captopril!!!)
So we´re going to use the next best quick solution – block them. We´re going to lay down a mine field with the help of an injectable drug called atipamezole. This is the perfect tool for the job…it´s not easy to find. Most will have settle for second best, which is yohimbine. Easy to find for oral use, but not for injections. Well, that doesn´t matter much. If don´t want to use it mixed with DMSO, ingestion is not that bad (but not best)
The last of the enemy´s forces are called adenosine receptors. The more the camp rises, the more adenosine will be found in the fat cells. This is because when camp is degraded it produces adenosine. It´s a negative feedback used by the body to make sure you are not losing fat too fast. We need to take care of the adenosine receptors by blocking them. Theophylline or caffeine will do the trick. If Amrinone is used, then theophylline will have to be used along with it. We have to burn the fat otherwise it will redeposited. This is called re-esterification. And when the fat is re-esterified it´s always in the wrong place.
The classic non-dieting way of ridding fat is weight training an aerobis
When we say aerobics, we do not mean slow speed 60% of your heart rate. We mean maximum speed. Enough energy is in the blood to stand it. Aerobics should be done first thing in the morning on an empty stomach. During the night, the body will have wasted all its carb-energy and will already rely on fat calories for energy. Absolutely NO eating beforehand. For two reasons:
1. Eating will bring in calories and so will spare fat calories we have in the blood.
2. Eating while taking a beta agonist an alpha 2 antagonist will result in a huge boost of insulin.
The insulin is like superior artillery which would defeat all of our armament, especially if we're not using the
phosphodiesterase inhibitor (amrinone).
If you're tired that means your body doesn't know how to convert the fat calories into a useable form of energy.
It will learn the hard way if you are waging TCW (total chemical warfare). Train as long as you can. When you cannot stand it any more, have a protein drink (Designer Whey seems to be the best). But remember no carbs. It will make you feel better and you can resume training. ,
Each day your goal will be to postpone the moment you take the drink. It will mean your body is learning how to use its fat for energy. Afterwards eat protein only. Try to postpone carb intake as much as possible. And remember, you're on a diet, don't stuffyour face.
The key is to start very low with only the beta agonist. ln a few days add the PDE inhibitor, then the alpha 2. Remember the doses should build up slowly. Too low a dose start won't hurt, For example, 1/2 a ml of clenbuterol will probably have no discernible effect. Next use day 1ml. See what happens.
Obviously, the injections go into the fat. But you do not want to go too deep. This is where insulin needles (without the insulin) are useful. Furthermore you don't want to inject in the same place everyday. One day high in the right buttock, and next day high in the left; the next day low in the right and so on. Divide the area you want to spot reduce into several squares. Use a different square everyday. You will need several injections to have all the drugs in place. Space those injections a little bit in your square.
Bin auf eure Postings gespannt
Gruß und einen schönen 1. Mai !
Patrick
