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NTP CHEMICAL REPOSITORY
2,4-DINITROPHENOL
-IDENTIFIERS
===========
*CATALOG ID NUMBER: 000500
*CAS NUMBER: 51-28-5
*BASE CHEMICAL NAME: DINITROPHENOL,2,4-
*PRIMARY NAME: 2,4-DINITROPHENOL
*CHEMICAL FORMULA: C6H4N2O5
*STRUCTURAL FORMULA: (NO2)2C6H3OH
*WLN: WNR BQ ENW
*SYNONYMS:
ALPHA-DINITROPHENOL
2,4-DNP
1-HYDROXY-2,4-DINITROBENZENE
NITROPHENE
NITROPHEN
PHENOL, 2,4-DINITRO-
PHENOL, ALPHA-DINITRO-
ALDIFEN
CHEMOX PE
FENOXYL CARBON N
SOLFO BLACK B
SOLFO BLACK BB
TERTROSULPHUR BLACK PB
DINOFAN
MAROXOL-50
RCRA WASTE NUMBER P048
SOLFO BLACK 2B SUPRA
SOLFO BLACK G
SOLFO BLACK SB
TERTROSULPHUR PBR
NITRO KLEENUP
NSC 1532
DNP
FENOXYL
-PHYSICAL CHEMICAL DATA
======================
*PHYSICAL DESCRIPTION: LITERATURE: Yellow crystals or powder
REPOSITORY: Yellow crystalline solid
*MOLECULAR WEIGHT: 184.11
*SPECIFIC GRAVITY: 1.683 [033,051,062,205]
*DENSITY: 1.683 g/mL @ 24 C [016,043,047,055]
*MP (DEG C): 112-114 C [033,205]
*BP (DEG C): Sublimes (when carefully heated) [016,029,033,051]
*SOLUBILITIES:
WATER : <1 mg/mL @ 19.5 C (RAD)
DMSO : 50-100 mg/mL @ 22 C (RAD)
95% ETHANOL : 10-50 mg/mL @ 22 C (RAD)
METHANOL : Not available
ACETONE : 50-100 mg/mL @ 22 C (RAD)
TOLUENE : 6.36 g/100 g @ 15 C [033]
OTHER SOLVENTS:
Chloroform: 5.39 g/100 g @ 15 C [033,205]
Ethyl acetate: 15.55 g/100 g @ 15 C [033]
Pyridine: 20.08 g/100 g @ 15 C [033,205]
Carbon tetrachloride: 0.423 g/100 g @ 15 C [033]
Ether: Soluble [016,062,295]
Benzene: Soluble [016,033,062,205]
Aqueous alkaline solutions: Soluble [033,173]
Alcohol: Soluble [016,033,205,295]
*VOLATILITY:
Vapor pressure: Not available
Vapor density : 6.35 [043,051]
*FLAMMABILITY(FLASH POINT):
Literature sources indicate that this chemical is flammable [051,275].
Its dust can form explosive mixtures in air [058]. Fires involving this
material can be controlled with a dry chemical, carbon dioxide or Halon
extinguisher. A water spray may also be used [058,269,371].
*UEL: Not available LEL: Not available
*REACTIVITY:
This chemical forms explosive salts with alkalies and ammonia [043,066].
It is incompatible with heavy metals and their compounds [058,346]. It is
also incompatible with strong oxidizers, strong bases and reducing agents
[269]. It reacts with combustibles [371].
*STABILITY:
This chemical may explode if subjected to heat or flame [058,371]. It
may explode if allowed to dry out [058]. Solutions of this chemical in water,
DMSO, 95% ethanol or acetone should be stable for 24 hours under normal lab
conditions (RAD).
*OTHER PHYSICAL DATA:
Melting point also reported as 106-108 C [275]
Sweet, musty odor [371]
pKa: 4.00 at 25 C [029]
pH range: 2.6 colorless, 4.4 yellow [033]
log P octanol: 1.51/1.54 [055]
Density: 1.68 g/mL @ 20 C [371]
Volatile with steam [029,033,173]
-TOXICITY
========
*NIOSH REGISTRY NUMBER: SL2800000
*TOXICITY: (abbreviations)
typ. dose mode specie amount units other
LDLo orl hmn 4300 ug/kg
LD50 orl rat 30 mg/kg
LD50 ipr rat 20 mg/kg
LD50 scu rat 25 mg/kg
LD50 orl mus 45 mg/kg
LD50 ipr mus 26 mg/kg
LDLo orl dog 30 mg/kg
LDLo scu dog 20 mg/kg
LDLo ivn dog 15 mg/kg
LD50 orl rbt 30 mg/kg
LDLo scu rbt 20 mg/kg
LD50 orl gpg 81 mg/kg
LDLo skn gpg 700 mg/kg
LDLo scu gpg 25 mg/kg
LD50 ims pgn 6500 ug/kg
LD50 unr mam 40 mg/kg
LD50 orl bwd 13 mg/kg
LCLo ihl dog 300 mg/m3/30M
LD50 orl cat 75 mg/kg
LD50 ipr gpg 28 mg/kg
*AQTX/TLM96: Not available
*SAX TOXICITY EVALUATION:
THR: A deadly human poison by ingestion. An experimental poison by ingestion,
inhalation, intravenous, intraperitoneal, subcutaneous, intramuscular
and possibly other routes. Moderately toxic by skin contact. An
experimental teratogen. Experimental reproductive effects. Mutagenic
data. A skin irritant. Phytotoxic.
*CARCINOGENICITY: Not available
*MUTATION DATA: See RTECS printout for most current data
*TERATOGENICITY: See RTECS printout for most current data
*STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): None
Flammability (F): None
Reactivity (R): None
*OTHER TOXICITY DATA:
Skin and Eye Irritation Data:
skn-rbt 300 mg/4W-I MLD
Review: Toxicology Review
Standards and Regulations: EPA FIFRA 1988 Pesticide Subject to Registration
or Re-registration
Status: EPA TSCA Chemical Inventory, 1989
EPA TSCA Test Submission (TSCATS) Data Base, April 1990
Acute fatal dose: ~1 g [301]
IDLH value: 5.0 mg/m3 [371]
-OTHER DATA (Regulatory)
=======================
*PROPER SHIPPING NAME (IATA): Dinitrophenol, wetted
*UN/ID NUMBER: UN1320
*HAZARD CLASS: 4.1 SUBSIDIARY RISK: 6.1 PACKING GROUP: I
*LABELS REQUIRED: Flammable solid and Poison
*PACKAGING: PASSENGER: PKG. INSTR.: 416 MAXIMUM QUANTITY: 1 kg
CARGO : PKG. INSTR.: 412 MAXIMUM QUANTITY: 15 kg
*SPECIAL PROVISIONS: A40
*USES:
This compound is used in the manufacture of dyes, diaminophenol,
wood preservatives, insecticides, explosives, herbicides, photographic
developers, picric acid and picramic acid. It is used as a reagent for the
detection of potassium and ammonium ions and in chemical synthesis. It is
also a useful tool in biochemical research. This compound was formerly used
as a metabolic stimulator to aid in weight reduction.
*COMMENTS:
The shipping information is for dinitrophenol, wetted with 15% or more
water (by weight).
-HANDLING PROCEDURES
===================
*ACUTE/CHRONIC HAZARDS:
This compound is toxic by inhalation, ingestion and skin contact [036,
058,295,346]. There is a danger of cumulative effects [036,151,295]. It is
a severe skin and eye irritant [043,058]. It is readily absorbed through the
skin [033,058]. Vapors are absorbed through the respiratory tract [033].
This compound is corrosive to the skin and mucous membranes [151]. When heated
to decomposition it emits toxic fumes of carbon monoxide, carbon dioxide and
nitrogen oxides [043,058,269].
*MINIMUM PROTECTIVE CLOTHING:
If Tyvek-type disposable protective clothing is not worn during
handling of this chemical, wear disposable Tyvek-type sleeves taped to
your gloves.
*RECOMMENDED GLOVE MATERIALS:
GlovES+ Expert System Glove Types For The Neat (Undiluted) Chemical:
This chemical has not been tested for permeation by Radian Corporation;
however, the GlovES+ expert system was used to extrapolate permeation test
information from compounds in the same chemical class. The GlovES+ system uses
permeation data from literature sources; therefore, extra safety margins should
be used with the estimated protection time(s). If this chemical makes direct
contact with your glove, or if a tear, puncture or hole develops, replace them
at once.
The GlovES+ expert system is a tool that can help people better manage
protection from chemicals, however this tool cannot replace sound judgment nor
make technical decisions. Our GlovES+ expert system is designed to offer
initial advice and assistance in glove selection while the final glove
selection should be made by knowledgeable individuals based on the specific
circumstances involved.
Glove Type Model Number Thickness Estimated Protection Time
Viton North F-091 0.25 mm 480 min
*RECOMMENDED RESPIRATOR:
Where the neat test chemical is stored, weighed and diluted, wear an
approved half face respirator equipped with a combination filter cartridge,
i.e. organic vapor/acid gas/HEPA, (specific for organic vapors, HCl, acid gas,
SO2 and a high efficiency particulate filter).
Splash proof safety goggles should be worn while handling this chemical.
Alternatively, a full face respirator, equipped as above, may be used to pro-
vide simultaneous eye and respiratory protection.
*OTHER: Not available
*STORAGE PRECAUTIONS:
You should store this chemical under refrigerated temperatures,
and keep it away from oxidizing materials. STORE AWAY FROM SOURCES
OF IGNITION.
*SPILLS AND LEAKAGE:
Should a spill occur while you are handling this chemical, FIRST REMOVE
ALL SOURCES OF IGNITION, then you should dampen the solid spill material with
60-70% ethanol and transfer the dampened material to a suitable container. Use
absorbent paper dampened with 60-70% ethanol to pick up any remaining material.
Seal the absorbent paper, and any of your clothes, which may be contaminated,
in a vapor-tight plastic bag for eventual disposal. Solvent wash all contamin-
ated surfaces with 60-70% ethanol followed by washing with a soap and water
solution. Do not reenter the contaminated area until the Safety Officer (or
other responsible person) has verified that the area has been properly cleaned.
*DISPOSAL AND WASTE TREATMENT: Not available
-EMERGENCY PROCEDURES
====================
*SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
IMMEDIATELY call a hospital or poison control center even if no symptoms
(such as redness or irritation) develop.
IMMEDIATELY transport the victim to a hospital for treatment after
washing the affected areas.
*INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
IMMEDIATELY call a physician and be prepared to transport the victim to a
hospital even if no symptoms (such as wheezing, coughing, shortness of breath,
or burning in the mouth, throat, or chest) develop.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
*EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
*INGESTION:
DO NOT INDUCE VOMITING. Phenols are very toxic poisons AND corrosive
and irritating, so that inducing vomiting may make medical problems worse.
IMMEDIATELY call a hospital or poison control center and locate activated
charcoal, egg whites, or milk in case the medical advisor recommends admini-
stering one of them.
If advice from a physician is not readily available and the victim is
conscious and not convulsing, give the victim a glass of activated charcoal
slurry in water or, if this is not available, a glass of milk, or beaten egg
whites and IMMEDIATELY transport victim to a hospital.
If the victim is convulsing or unconscious, do not give anything by mouth,
assure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
*SYMPTOMS:
Symptoms of exposure to this compound may include profuse sweating,
fever, shortness of breath and yellow coloration of the skin of the hands
and feet [036]. Other symptoms may include a marked increase in metabolism,
nausea, vomiting, collapse, death, cataracts, weight loss, granulocytopenia,
polyneuropathy and exfoliative dermatitis [033]. Skin irritation may also
occur [043]. Exposure to this compound may also cause disruption of oxidative
phosphorylation, increased oxygen consumption, fatigue, intense thirst, sweat-
ing, oppression of the chest, anorexia, weakness, dizziness, vertigo, headache,
sensitivity of the liver to pressure, jaundice and hypersensitivity, neutro-
penia, skin rashes and peripheral neuritis [346]. Other symptoms may include
degenerative changes in the heart, liver and kidneys, cyanosis, lividity,
tremors and coma [301]. Contact may also cause irritation of the eyes and
mucous membranes [269]. Secondary glaucoma may also result [099]. Exposure
to this compound may cause restlessness, flushed skin, tachycardia and fatal
hyperthermia [406]. Allergic reactions may also occur [051]. Other symptoms
may include hyperpyrexia, acidosis, dehydration, muscle rigor, pulmonary edema,
abdominal pain and diarrhea [151]. Anxiety and delirium may also result [430].
Other symptoms may include liver damage, dilation of the pupils, smarting of
the skin and skin burns [371].
