redfox1
New member
Hi!
Nachdem ich ja aufgrund des intensiven Trainings (und meines wohl von Grund auf verletzungsanfälligen Körpers) Probleme mit den Gelenken habe, bin ich immer auf der suche nach legalen Mitteln, welche mir ein "schmerzfreieres" Training ermöglichen können.
Neben Glucosamin,MSM und Chonditrin (was haltet ihr übrigens davon?) bin ich jetzt auf C.M. Plex von Unicity gestoßen. Soll laut Studien (siehe unten) ähnliche Effekte wie Celebrex haben.
Nachdem ich von Voltaren und co nichts als Magengeschwüre bekommen habe und Celebrex ja auch (wenn auch weniger) NEbewirkungen hat, hab ich mir gedacht, dass könnte ja eine Alternative sein.
Problem: Ist sehr teuer (knapp 50 Euro pro Monat)
Hat jemand von euch schon Erfahrungen mit dem Produkt gemacht bzw. wie findet ihr die studien dazu? Sind die aussagekräftig?
Zum Produkt selber:
Lipid - Komplex
Die Verfügbarkeit von Nährstoffen für Körperzellen ist besonders wichtig für Gewebe und Organe, die unter starker Belastung stehen. Dies trifft für aktive Menschen ganz besonders zu.
Fettsäureester sind wichtige Nährstoffe, die sich auch in Zellmembranen finden und zu einer normalen Organ- und Gewebefunktion beitragen.
CM Plex™ enthält eine Mischung aus den Fettsäureestern Cetylmyristat und Cetylmyristoleat sowie weiteren Lipiden, die gesunde Gewebe und Körperstrukturen unterstützen.
Zutaten:
Cetylmyristat, Sojaöl, Gelatine, Cetylmyristoleat, Olivenöl, Glycerin, Lachsöl, Verdickungsmittel: Johannisbrotkernmehl, Cetylpalmitoleat, Cetylaurat, Cetylpalmitat, Antioxidationsmittel: Tocopherol, Cetyloleat.
Verzehrempfehlung:
2 Kapseln mit einem großen Glas Wasser zu den Mahlzeiten verzehren.
Hier die Studien dazu:
Rheumatol. 2002 Aug;29(8):1708-12.
Cetylated fatty acids improve knee function in patients with osteoarthritis.
Hesslink R Jr, Armstrong D 3rd, Nagendran MV, Sreevatsan S, Barathur R.
Hesslink Ventures, San Diego, California, USA.
OBJECTIVE: To determine the benefit of cetylated fatty acids (CFA) on knee range of motion and function in patients with osteoarthritis (OA). METHODS: Sixty-four patients with chronic knee OA were evaluated at baseline and at 30 and 68 days after consuming either placebo (vegetable oil; n = 31) or CFA (Celadrin; n = 33). Evaluations included physician assessment, knee range of motion with goniometry, and the Lequesne Algofunctional Index (LAI). RESULTS: After 68 days, patients treated with CFA exhibited significant (p < 0.001) increase in knee flexion (10.1 degrees) compared to patients given placebo (1.1 degrees). Neither group reported improvement in knee extension. Patient responses to the LAI indicated a significant (p < 0.001) shift towards functional improvement for the CFA group (-5.4 points) after 68 days compared to a modest improvement in the placebo group (-2.1 points). CONCLUSION: Compared to placebo, CFA provides an improvement in knee range of motion and overall function in patients with OA of the knee. CFA may be an alternative to the use of nonsteroidal antiinflammatory drugs for the treatment of OA.
Pharmacol Res. 2003 Jan;47(1):43-7.
Synthesis of cetyl myristoleate and evaluation of its therapeutic efficacy in a murine model of collagen-induced arthritis.
Hunter KW Jr, Gault RA, Stehouwer JS, Tam-Chang SW.
Department of Microbiology, University of Nevada School of Medicine, Reno, NV 89557, USA. khunter@unr.edu
Cetyl myristoleate (CM) was reported by Diehl and May [J Pharm Sci 83 (1994) 296] to block inflammation and prevent adjuvant-induced arthritis in rats. To verify this earlier work, we have synthesized pure CM and tested its anti-arthritic properties in a collagen-induced arthritis model in DBA/1LacJ mice. Multiple intraperitoneal injections of CM in 450 and 900 mg kg(-1) doses resulted in a significantly lower incidence of disease and caused a modest but significant diminution in clinical signs in those mice that developed arthritis. CM administered in daily oral doses of 20 mg kg(-1) also reduced the incidence of arthritis and caused a small reduction in the clinical signs in mice that developed arthritis. Although the protective effect of CM in collagen-induced arthritis observed in the present study was less dramatic than that reported earlier, our results confirm the anti-arthritic properties of pure CM.
Am Fam Physician. 2003 Jan 15;67(2):339-44
Alternative therapies for traditional disease states: osteoarthritis.
Morelli V, Naquin C, Weaver V.
Family Practice Residency Program, Louisiana State University Health Sciences Center, Kenner, Louisiana 70065, USA.
Americans spend more on natural remedies for osteoarthritis than for any other medical condition. In treating osteoarthritis, glucosamine and chondroitin sulfate, two of the molecular building blocks found in articular cartilage, are the most commonly used alternative supplements. In randomized trials of variable quality, these compounds show efficacy in reducing symptoms, but neither has been shown to arrest progression of the disease or regenerate damaged cartilage. Although few clinical trials on S-adenosylmethionine exist, preliminary evidence indicates that it relieves pain to a degree similar to that of nonsteroidal anti-inflammatory drugs but with fewer side effects. Clinical trials of dimethyl sulfoxide offer conflicting results. Neither ginger nor cetyl myristoleate has proven clinical usefulness.
J Pharm Sci. 1994 Mar;83(3):296-9.
Cetyl myristoleate isolated from Swiss albino mice: an apparent protective agent against adjuvant arthritis in rats.
Diehl HW, May EL.
Department of Pharmacology, Medical College of Virginia, Richmond 23298.
Cetyl myristoleate was isolated from National Institutes of Health, general purpose, Swiss albino mice that were immune to the polyarthritis induced in rats with Freund's adjuvant. This substance, or material synthesized from cetyl alcohol and myristoleic acid, afforded good protection against adjuvant-induced arthritic states in rats. In limited comparisons, cetyl oleate, also found in Swiss albino mice, gave lesser protection, whereas cetyl myristate and cetyl elaidate, the trans-isomer of cetyl oleate, appeared to be virtually ineffective. Dosage of the protective compound as well as the site of injection of Freund's adjuvant was important.
mfg,
redfox!
Nachdem ich ja aufgrund des intensiven Trainings (und meines wohl von Grund auf verletzungsanfälligen Körpers) Probleme mit den Gelenken habe, bin ich immer auf der suche nach legalen Mitteln, welche mir ein "schmerzfreieres" Training ermöglichen können.
Neben Glucosamin,MSM und Chonditrin (was haltet ihr übrigens davon?) bin ich jetzt auf C.M. Plex von Unicity gestoßen. Soll laut Studien (siehe unten) ähnliche Effekte wie Celebrex haben.
Nachdem ich von Voltaren und co nichts als Magengeschwüre bekommen habe und Celebrex ja auch (wenn auch weniger) NEbewirkungen hat, hab ich mir gedacht, dass könnte ja eine Alternative sein.
Problem: Ist sehr teuer (knapp 50 Euro pro Monat)
Hat jemand von euch schon Erfahrungen mit dem Produkt gemacht bzw. wie findet ihr die studien dazu? Sind die aussagekräftig?
Zum Produkt selber:
Lipid - Komplex
Die Verfügbarkeit von Nährstoffen für Körperzellen ist besonders wichtig für Gewebe und Organe, die unter starker Belastung stehen. Dies trifft für aktive Menschen ganz besonders zu.
Fettsäureester sind wichtige Nährstoffe, die sich auch in Zellmembranen finden und zu einer normalen Organ- und Gewebefunktion beitragen.
CM Plex™ enthält eine Mischung aus den Fettsäureestern Cetylmyristat und Cetylmyristoleat sowie weiteren Lipiden, die gesunde Gewebe und Körperstrukturen unterstützen.
Zutaten:
Cetylmyristat, Sojaöl, Gelatine, Cetylmyristoleat, Olivenöl, Glycerin, Lachsöl, Verdickungsmittel: Johannisbrotkernmehl, Cetylpalmitoleat, Cetylaurat, Cetylpalmitat, Antioxidationsmittel: Tocopherol, Cetyloleat.
Verzehrempfehlung:
2 Kapseln mit einem großen Glas Wasser zu den Mahlzeiten verzehren.
Hier die Studien dazu:
Rheumatol. 2002 Aug;29(8):1708-12.
Cetylated fatty acids improve knee function in patients with osteoarthritis.
Hesslink R Jr, Armstrong D 3rd, Nagendran MV, Sreevatsan S, Barathur R.
Hesslink Ventures, San Diego, California, USA.
OBJECTIVE: To determine the benefit of cetylated fatty acids (CFA) on knee range of motion and function in patients with osteoarthritis (OA). METHODS: Sixty-four patients with chronic knee OA were evaluated at baseline and at 30 and 68 days after consuming either placebo (vegetable oil; n = 31) or CFA (Celadrin; n = 33). Evaluations included physician assessment, knee range of motion with goniometry, and the Lequesne Algofunctional Index (LAI). RESULTS: After 68 days, patients treated with CFA exhibited significant (p < 0.001) increase in knee flexion (10.1 degrees) compared to patients given placebo (1.1 degrees). Neither group reported improvement in knee extension. Patient responses to the LAI indicated a significant (p < 0.001) shift towards functional improvement for the CFA group (-5.4 points) after 68 days compared to a modest improvement in the placebo group (-2.1 points). CONCLUSION: Compared to placebo, CFA provides an improvement in knee range of motion and overall function in patients with OA of the knee. CFA may be an alternative to the use of nonsteroidal antiinflammatory drugs for the treatment of OA.
Pharmacol Res. 2003 Jan;47(1):43-7.
Synthesis of cetyl myristoleate and evaluation of its therapeutic efficacy in a murine model of collagen-induced arthritis.
Hunter KW Jr, Gault RA, Stehouwer JS, Tam-Chang SW.
Department of Microbiology, University of Nevada School of Medicine, Reno, NV 89557, USA. khunter@unr.edu
Cetyl myristoleate (CM) was reported by Diehl and May [J Pharm Sci 83 (1994) 296] to block inflammation and prevent adjuvant-induced arthritis in rats. To verify this earlier work, we have synthesized pure CM and tested its anti-arthritic properties in a collagen-induced arthritis model in DBA/1LacJ mice. Multiple intraperitoneal injections of CM in 450 and 900 mg kg(-1) doses resulted in a significantly lower incidence of disease and caused a modest but significant diminution in clinical signs in those mice that developed arthritis. CM administered in daily oral doses of 20 mg kg(-1) also reduced the incidence of arthritis and caused a small reduction in the clinical signs in mice that developed arthritis. Although the protective effect of CM in collagen-induced arthritis observed in the present study was less dramatic than that reported earlier, our results confirm the anti-arthritic properties of pure CM.
Am Fam Physician. 2003 Jan 15;67(2):339-44
Alternative therapies for traditional disease states: osteoarthritis.
Morelli V, Naquin C, Weaver V.
Family Practice Residency Program, Louisiana State University Health Sciences Center, Kenner, Louisiana 70065, USA.
Americans spend more on natural remedies for osteoarthritis than for any other medical condition. In treating osteoarthritis, glucosamine and chondroitin sulfate, two of the molecular building blocks found in articular cartilage, are the most commonly used alternative supplements. In randomized trials of variable quality, these compounds show efficacy in reducing symptoms, but neither has been shown to arrest progression of the disease or regenerate damaged cartilage. Although few clinical trials on S-adenosylmethionine exist, preliminary evidence indicates that it relieves pain to a degree similar to that of nonsteroidal anti-inflammatory drugs but with fewer side effects. Clinical trials of dimethyl sulfoxide offer conflicting results. Neither ginger nor cetyl myristoleate has proven clinical usefulness.
J Pharm Sci. 1994 Mar;83(3):296-9.
Cetyl myristoleate isolated from Swiss albino mice: an apparent protective agent against adjuvant arthritis in rats.
Diehl HW, May EL.
Department of Pharmacology, Medical College of Virginia, Richmond 23298.
Cetyl myristoleate was isolated from National Institutes of Health, general purpose, Swiss albino mice that were immune to the polyarthritis induced in rats with Freund's adjuvant. This substance, or material synthesized from cetyl alcohol and myristoleic acid, afforded good protection against adjuvant-induced arthritic states in rats. In limited comparisons, cetyl oleate, also found in Swiss albino mice, gave lesser protection, whereas cetyl myristate and cetyl elaidate, the trans-isomer of cetyl oleate, appeared to be virtually ineffective. Dosage of the protective compound as well as the site of injection of Freund's adjuvant was important.
mfg,
redfox!
