The genetic architecture of changes in adiposity during adulthood

[alligatorob]

Not yet peer reviewed, but it should be soon and I think well worth reading. Here is a quote I particularly appreciated:

The heritability of body mass index (BMI) is estimated to be 40%–70%, and genome-wide association studies (GWASs) have implicated over 1,000 independent loci associated with a range of obesity traits.

I have long believed my problems are due to inheriting more genes that favor overeating than most people. This paper indicates that is at least a possibility. Those genes would have been of benefit to my ancestors in food scarce times, not so much today. Doesn't mean I shouldn't continue to find a way to live with it... I will. Giving up is not an option.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882550/

 

[Cate]

Thanks for the article, Rob. I'm fairly sure I share most of my father's genetic traits, including struggling with my weight. I have always thought that genetics plays a huge part. I'll have a good read tomorrow. Cheers, Cate.

 

[macness]

Genetics plays a bigger role than many people realize, and it's validating to see research backing that up. You're right that genes that once helped our ancestors survive during famine may now make it harder to manage weight in today's world of constant food availability.