My suggestion would be the following:
1) Don't make it an either or proposition... some isolation work is okay, especially if you're goal right now is hypertrophy.
2) Make sure hypertrophy actually is your goal and it doesn't oppose other goals you have right now, such as fat loss.
3) Don't become married to one particular rep range. Varying the intensity and therefore the rep range across the week can be a good thing on a few levels.
4) From the sounds of it, if I were you, and granted I don't know enough about you to give specific advice, I'd follow something like a full body routine where you train 3 days per week hitting all the major muscle groups each time. Place a premium on things like mastery of form before you start worrying about getting stronger.
An example of how you could set something up, which isn't set in stone AT ALL would be:
Day 1 - Heavy (3-4 sets of 4-6 reps)
Day 2 - Light (fast) (5-6 sets of 3 reps)
Day 3 - Medium (3-5 sets of 10-12 reps)
This isn't necessarily the case, but you could think of the heavy day as a pure strength day, the light day as a power day, and the medium day as a hypertrophy day.
Depending on your experience, I would most likely modify this. For instance, if you haven't spend a lot of time under the bar, I'd probably interchange the light/fast work for just lighter work. Don't point in building power if you don't have a nice foundation of strength already, IMO.
For the heavy day, a solid selection of exercises would be
Back Squat
Bench Press
Barbell Row
Assistance
For the light fast day, a solid selection of exercises would be
Front Squat or Leg Press
Overhead Press
Pullup (or pulldown)
Assistance
For the medium day a solid selection of exercises could be
Back Squat
DB Incline Bench
DB Rows
Assistance
Assistance is merely supplemental movements such as direct arm work, core work, and prehab/rehab stuff.
Bear in mind that the exercise choices, while solid, are still somewhat arbitrary. If you want to sub one kind of squat for another, or one kind of press for another, there's no problem with that.