Dietary fat stored more easily than carbs

Ok, I was just unsure if you were agreeing and just adding additional info, or if you had misunderstood what I meant and was arguing against me :p

I don't know under what conditions the fuel shift would be bad.. or if it would be bad at all. I don't think there is a lot of research to support that high carb diets lead to diebetes and what not, but it's all epidemiological and not controlled. I'm gonna see if I can find any RCTs on high carb diets and insulin resistance.
 
Good article, Karky. I just stumbled upon an article by Gary Taubes in New York Times Magazine. You can check it out , it kinda gives a huge blow to the whole American Medical Establishment which has pushed these high-refined carb and low-fat diets on Americans for over 25 years now, with visibly disastrous consequences.
 
rupindersayal said:
Good article, Karky. I just stumbled upon an article by Gary Taubes in New York Times Magazine. You can check it out , it kinda gives a huge blow to the whole American Medical Establishment which has pushed these high-refined carb and low-fat diets on Americans for over 25 years now, with visibly disastrous consequences.
Click to expand...

That's a good article. However, Taubes = not the best source.
 
Taubes makes some good points in his arguments, but yeah, not the best source.
Insulin isn't he only regulator of fat storage.. there is Acetyl stimulating protein (ASP) aswell, which is increases about 200-300 fold by cylomicrons (which is how the body transports dietary fat).

His main argument is about alpha glycerl 3 phosphate, though. He says you need that to make triglycerides from fatty acids inside the adipocytes and the only way you can get this is from carbs. (as well as the glycerol part of fat, but he doesn't mention that)
I'm not sure if you'd get a shortage of this substance from eating low carb, and if you did get a shortage, I'm not sure how that would affect the body. Would be cool if someone knew, though.
 
Karky said:
Ok, I was just unsure if you were agreeing and just adding additional info, or if you had misunderstood what I meant and was arguing against me :p

I don't know under what conditions the fuel shift would be bad.. or if it would be bad at all. I don't think there is a lot of research to support that high carb diets lead to diebetes and what not, but it's all epidemiological and not controlled. I'm gonna see if I can find any RCTs on high carb diets and insulin resistance.
Click to expand...

arly responses of insulin sensitivity to high-carbohydrate and high-fat overfeeding

--------------------------------------------------------------------------------

Early responses of insulin sensitivity to high-carbohydrate and high-fat overfeeding
Rebecca L Adochio email, J WAYNE Leitner email, Karen Gray email, Boris Draznin email and Marc-Andre Cornier email

Nutrition & Metabolism 2009, 6:37doi:10.1186/1743-7075-6-37
Published: 28 September 2009

Background

Early molecular changes of nutritionally-induced insulin resistance are still enigmatic. It is also unclear if acute overnutrition alone can alter insulin signaling in humans or if the macronutrient composition of the diet can modulate such effects.

Methods

To investigate the molecular correlates of metabolic adaptation to either high-carbohydrate (HC) or high-fat (HF) overfeeding, we conducted overfeeding studies in 21 healthy lean (BMI <25) individuals (10 women, 11 men), age 20-45, with normal glucose metabolism and no family history of diabetes. Subjects were studied first following a 5-day eucaloric (EC) diet (30% fat, 50% CHO, 20% protein) and then in a counter balanced manner after 5 days of 40% overfeeding of both a HC (20% fat, 60% CHO) diet and a HF (50% fat, 30% CHO) diet. At the end of each diet phase, in vivo insulin sensitivity was assessed using the hyperinsulinemic-euglycemic clamp technique. Ex vivo insulin action was measured from skeletal muscle tissue samples obtained 15 minutes after insulin infusion was initiated.

Results

Overall there was no change in whole-body insulin sensitivity as measured by glucose disposal rate (GDR, EC: 12.1 +/- 4.7; HC: 10.9 +/- 2.7; HF: 10.8 +/- 3.4). Assessment of skeletal muscle insulin signaling demonstrated increased tyrosine phosphorylation of IRS-1 (p<0.001) and increased IRS-1-associated phosphatidylinositol 3 (PI 3)-kinase activity (p<0.001) following HC overfeeding. In contrast, HF overfeeding increased skeletal muscle serine phosophorylation of IRS-1 (p<0.001) and increased total expression of p85alpha (P<0.001).

Conclusions

We conclude that acute bouts of overnutrition lead to changes at the cellular level before whole-body insulin sensitivity is altered. On a signaling level, HC overfeeding resulted in changes compatible with increased insulin sensitivity. In contrast, molecular changes in HF overfeeding were compatible with a reduced insulin sensitivity.
 
Pretty logical that short term overfeeding of carbs leads to a better more phosphorylation of IRS-1 since the body needs to be able to do something with all those carbs, and that requires a higher carb uptake. I wonder if the long term effects could be bad.

I've often heard of high dietary fat causing insulin resistance, but most often I've just seen animal studies. and in the few human studies I've seen, insulin resistance has been preceded by fat gain, which means dietary fat directly the culprit, but the weight gain associated with high dietary fat leads to insulin resistance (which makes sense based on adipokines and what not).

Dietary factors that lead to insulin resistance both in ad libitum (eat as you want, no restrictions or anything), eucaloric, and hyper-and hypocaloric situations is a really interesting subject. I need to read more up on that.
 
i have often wondered for years the inuit (eskimos) ate nothing but fat and protein,i wonder how there bodies have adapted to carbs now it is accessable to them,that would be an interesting study
 
3) These patterns are repeated across society. Since the low-fat diets were accepted and promoted by our Government, rates of obesity have trebled.
Click to expand...
wouldnt surprise me marek,but is that because people who lower there fat intake probably increase something else
Overconsumption of fat does not make people as fat as overconsumption of carbs
Click to expand...
.
also dont really understand what you mean by this,surely if you overconsume anything you are going to gan weight,are you saying that if you overconsume carbs by 500cals that you will gain more weight than if you overconsumed 500cals of fat if so why.
 
You must log in or register to reply here.
Back
Top