absolutely.
with *most* lifts, you're going to inhale during the eccentric phase of the exercise, and exhale during the concentric phase.
example: bench press - breath in while lowering the weight to your chest, and then exhale as you push it back up.
some lifts are going to benefit from holding your breath during the first half of the concentric phase, as this helps stabilize the core. primary example is squats...you need a solid core so you shouldn't exhale until you're 50-60% back 'up' from the squat.